Creatine Kinase


Williams GZ, Widdowson GM and Penton J, 1978, Clin Chem, 24, 313-20 , Individual Character of Variation in Time-Series Studies of Healthy People II. Differences in Values for Clinical Chemical Analytes in Serum among Demographic Groups by Age and Sex


Total Score


Parameter Score
1. Scale A
2. Study Population A
3. Samples B
4. Measurand C
5. Pre-Analytical C
6. Replicate Analysis B
7. Steady State B
8. Outlier Analysis C
9. Normality A
10. Variance Homogeneity C
12. CI A
13. No of Results C
14. Concentrations A
15. Total Score C4,5,8,10,13

Item Details

Parameter Score
Matrix Serum
Measurand Creatine Kinase
Unit U / L
Overall Analytical Principle Method Enzymatic analysis - Not specified
Number of Subjects 811
Number of Subjects included in BV estimation 811
Ethinicity Unknown
Age Mean / Median
Age Min 18.0
Age Max
Age SD
Number of Males 436
Number of Females 375
State of Well Being
Healthy (excl pregnant)
Study Duration Length 62
Study Duration Units Week
Sampling Intervals, e.g. X sample(s) per Interval Unit 1
Interval Units Week
Sampling Times Start Time: 07:30
End Time: 10:00
Number of Samples 5
Average Number of Samples Used for BV Estimation 5.0
Average Number of Replicates 1.0
Estimates of CVi 12.6
Calculated Confidence Intervals of CVi Lower: 0.00, Upper: 18.82
Estimates of CVg 11.8
Calculated Confidence Intervals of CVg Lower: 8.06, Upper: 14.98
Analytical CV 3.8
Calculated Confidence Intervals of Analytical CV Lower: 3.56, Upper: 4.08
Measurand Mean 38.0
Measurand Min
Measurand Max
Measurand SD