Haemoglobin A1c (IFCC)

Reference

Reference
Braga F, Dolci A, Montagnana M, Pagani F, Paleari R, Guidi GC, Mosca A and Panteghini M, 2011, Clin Chim Acta, 412, 1412-6 , Revaluation of biological variation of glycated hemoglobin (HbA1c) using an accurately designed protocol and an assay traceable to the IFCC reference system

Scoring

Total Score

B7,9

Parameter Score
1. Scale A
2. Study Population A
3. Samples A
4. Measurand A
5. Pre-Analytical A
6. Replicate Analysis A
7. Steady State B
8. Outlier Analysis A
9. Normality B
10. Variance Homogeneity A
11. ANOVA A
12. CI A
13. No of Results A
14. Concentrations A
15. Total Score B7,9
Comment

Item Details

Parameter Score
Matrix Whole Blood EDTA
Measurand Haemoglobin A1c (IFCC)
Unit mmol / mol
Overall Analytical Principle Method Immunoturbidimetry
Number of Subjects 9
Number of Subjects included in BV estimation 9
Ethinicity Caucasian
Age Mean / Median
Age Min 26.0
Age Max 52.0
Age SD
Number of Males 9
Number of Females 0
State of Well Being
Healthy (excl pregnant)
Diseases
Study Duration Length 2
Study Duration Units Month
Sampling Intervals, e.g. X sample(s) per Interval Unit 2
Interval Units Week
Sampling Times Start Time:
End Time:
Number of Samples 5
Average Number of Samples Used for BV Estimation 5.0
Average Number of Replicates 2.0
Estimates of CVi 1.9
Calculated Confidence Intervals of CVi Lower: 0.92, Upper: 2.85
Estimates of CVg 8.9
Calculated Confidence Intervals of CVg Lower: 6.06, Upper: 16.34
Analytical CV 2.4
Calculated Confidence Intervals of Analytical CV Lower: 1.99, Upper: 3.02
Measurand Mean 36.5
Measurand Min
Measurand Max
Measurand SD

Coding