Haemoglobin A1c (HbA1c)

Reference

Reference
Carlsen S, Petersen PH, Skeie S, Skadberg O and Sandberg S, 2011, Clin Chem Lab Med, 49, 1501-7 , Within subject biological variation of glucose and HbA1c in healthy persons and in type 1 diabetes patients

Scoring

Total Score

A1,2,3,4,5,6,7,8,9,10,11,12,13,14

Parameter Score
1. Scale A
2. Study Population A
3. Samples A
4. Measurand A
5. Pre-Analytical A
6. Replicate Analysis A
7. Steady State A
8. Outlier Analysis A
9. Normality A
10. Variance Homogeneity A
11. ANOVA A
12. CI A
13. No of Results A
14. Concentrations A
15. Total Score A1,2,3,4,5,6,7,8,9,10,11,12,13,14
Comment HPLC standardized to DCCT

Item Details

Parameter Score
Matrix Whole blood
Measurand Haemoglobin A1c (HbA1c)
Unit mmol / mol
Overall Analytical Principle Method Spectrophotometry; UV/VISIBLE
Number of Subjects 15
Number of Subjects included in BV estimation 14
Ethinicity Unknown
Age Mean / Median
Age Min 27.0
Age Max 59.0
Age SD
Number of Males 6
Number of Females 9
State of Well Being
Non-healthy (excl pregnant)
Diseases
Study Duration Length 70
Study Duration Units Day
Sampling Intervals, e.g. X sample(s) per Interval Unit
Interval Units Week
Sampling Times Start Time:
End Time:
Number of Samples 10
Average Number of Samples Used for BV Estimation 8.5
Average Number of Replicates 2.0
Estimates of CVi 1.7
Calculated Confidence Intervals of CVi Lower: 1.48, Upper: 1.98
Estimates of CVg 8.2
Calculated Confidence Intervals of CVg Lower: 5.99, Upper: 12.95
Analytical CV 0.6
Calculated Confidence Intervals of Analytical CV Lower: 0.53, Upper: 0.69
Measurand Mean 53.0
Measurand Min 52.0
Measurand Max 54.0
Measurand SD

Coding